Optimal management of multiple sclerosis during pregnancy: current perspectives

Multiple sclerosis (MS) is a common inflammatory demyelinating disorder of the central nervous system. It frequently affects females in their reproductive phase of life. Therefore, family planning, pregnancy, and breastfeeding are important issues in the management of MS, particularly with respect to counseling and drug treatment. This paper reviews currently available data on the outcome of pregnancies in MS patients and the influence of pregnancy on the course of the disease. We give an update on the use of various disease-modifying MS drugs during pregnancy and breastfeeding. In addition to established therapies such as interferon-{beta}, glatiramer acetate, natalizumab, and fingolimod, we also discuss the state of knowledge about new agents such as dimethyl fumarate, teriflunomide, and alemtuzumab in the context of pregnancy and breastfeeding

Searching for Radio Pulsars in 3EG Sources at Urumqi Observatory

Since mid-2005, a pulsar searching system has been operating at 18 cm on the 25-m radio telescope of Urumqi Observatory. Test observations on known pulsars show that the system can perform the intended task. The prospect of using this system to observe 3EG sources and other target searching tasks is discussed.Comment: a training project about MSc thesi

Predictive Modeling for Navy Readiness Based on Resource Investment in Supply Support and Maintenance

NPS NRP Executive SummaryThe Navy invests substantial resources to fleet maintenance in terms of part supply, corrective maintenance, maintenance availabilities, and overhauls. In order to measure and prioritize weapon systems investment decisions, an endurance supply metric (Es)is being developed to ensure these systems are ready for tasking across the full spectrum of operations. This research project will attempt to extend the endurance supply concept beyond a single ship by determining what would be the endurance supply for a given group of ships within line of sight of each other and assuming they could transfer parts from one ship to another. The effort will also determine the endurance supply for a single ship assuming resupply from the wholesale system is allowed. The research will provide guidance to what data should the Navy capture to make better decisions using the Es metric.N4 - Fleet Readiness & LogisticsThis research is supported by funding from the Naval Postgraduate School, Naval Research Program (PE 0605853N/2098). https://nps.edu/nrpChief of Naval Operations (CNO)Approved for public release. Distribution is unlimited.

Predictive Modeling for Navy Readiness Based on Resource Investment in Supply Support and Maintenance

NPS NRP Project PosterThe Navy invests substantial resources to fleet maintenance in terms of part supply, corrective maintenance, maintenance availabilities, and overhauls. In order to measure and prioritize weapon systems investment decisions, an endurance supply metric (Es)is being developed to ensure these systems are ready for tasking across the full spectrum of operations. This research project will attempt to extend the endurance supply concept beyond a single ship by determining what would be the endurance supply for a given group of ships within line of sight of each other and assuming they could transfer parts from one ship to another. The effort will also determine the endurance supply for a single ship assuming resupply from the wholesale system is allowed. The research will provide guidance to what data should the Navy capture to make better decisions using the Es metric.N4 - Fleet Readiness & LogisticsThis research is supported by funding from the Naval Postgraduate School, Naval Research Program (PE 0605853N/2098). https://nps.edu/nrpChief of Naval Operations (CNO)Approved for public release. Distribution is unlimited.

Predictive Modeling for Navy Readiness Based on Resource Investment in Supply Support and Maintenance

NPS NRP Technical ReportThe Navy invests substantial resources to fleet maintenance in terms of part supply, corrective maintenance, maintenance availabilities, and overhauls. In order to measure and prioritize weapon systems investment decisions, an endurance supply metric (Es)is being developed to ensure these systems are ready for tasking across the full spectrum of operations. This research project will attempt to extend the endurance supply concept beyond a single ship by determining what would be the endurance supply for a given group of ships within line of sight of each other and assuming they could transfer parts from one ship to another. The effort will also determine the endurance supply for a single ship assuming resupply from the wholesale system is allowed. The research will provide guidance to what data should the Navy capture to make better decisions using the Es metric.N4 - Fleet Readiness & LogisticsThis research is supported by funding from the Naval Postgraduate School, Naval Research Program (PE 0605853N/2098). https://nps.edu/nrpChief of Naval Operations (CNO)Approved for public release. Distribution is unlimited.

Effect of Particle Size on Droplet Infiltration into Hydrophobic Porous Media As a Model of Water Repellent Soil

The wettability of soil is of great importance for plants and soil biota, and in determining the risk for preferential flow, surface runoff, flooding,and soil erosion. The molarity of ethanol droplet (MED) test is widely used for quantifying the severity of water repellency in soils that show reduced wettability and is assumed to be independent of soil particle size. The minimum ethanol concentration at which droplet penetration occurs within a short time (≤10 s) provides an estimate of the initial advancing contact angle at which spontaneous wetting is expected. In this study, we test the assumption of particle size independence using a simple model of soil, represented by layers of small (0.2–2 mm) diameter beads that predict the effect of changing bead radius in the top layer on capillary driven imbibition. Experimental results using a three-layer bead system show broad agreement with the model and demonstrate a dependence of the MED test on particle size. The results show that the critical initial advancing contact angle for penetration can be considerably less than 90° and varies with particle size, demonstrating that a key assumption currently used in the MED testing of soil is not necessarily valid

Expert recommendations to personalization of medical approaches in treatment of multiple sclerosis: an overview of family planning and pregnancy

Multiple sclerosis is the most common chronic autoimmune disease of the central nervous system which preferentially affects females at childbearing age. For this reason, patients and treating physicians were frequently confronted with questions concerning family planning, pregnancy and birth. Preventive and personalized treatment approaches are considered, because topics as heredity, risk of congenital malformations, influence of pregnancy on MS and aspects of drug therapy during the period of conception, pregnancy, puerperium and lactation have to be discussed. Here, we provide an overview about the current state of knowledge regarding these issues

OntoMathPROOntoMath^{PRO} Ontology: A Linked Data Hub for Mathematics

In this paper, we present an ontology of mathematical knowledge concepts that covers a wide range of the fields of mathematics and introduces a balanced representation between comprehensive and sensible models. We demonstrate the applications of this representation in information extraction, semantic search, and education. We argue that the ontology can be a core of future integration of math-aware data sets in the Web of Data and, therefore, provide mappings onto relevant datasets, such as DBpedia and ScienceWISE.Comment: 15 pages, 6 images, 1 table, Knowledge Engineering and the Semantic Web - 5th International Conferenc

Mechanism of tribo-chemical reactions of ionic liquids on titanium alloys

In this paper, the tribological, the tribo-chemical reaction mechanisms and desorption properties of three ionic liquids (ILs), [Bu3MeP][ Tf2N], [Bu3MeN][ Tf2N] and [Bu3MeP][ (MeO)2PO2], in contact with titanium and under vacuum conditions are studied with the CATRI © UHV Tribometer developed by IK4-TEKNIKER [1]. The two ILs containing the bis(trifluoromethanesulfonyl)amide anion presented lower coefficient of friction compared to that having the dimethyl phosphate anion. The tribodesorption study revealed that it is required an induction period to decrease the friction coefficient. The end of this period is accelerated in the case of trifluoromethane ionic liquids by the CF3+ release. Hence, the CF3+ reacts with the titanium surface generating a titanium fluoride tribolayer that could act like a catalyst to generate the tribodesorption of ionic liquid cation fragments (CH3+, C2H5+, C3H7+, C4H9+). The XPS analysis confirmed the generation of a boundary film, comprising of sulfide and inorganic fluoride, and being possibly the responsible of decreasing the friction coefficient. The [Bu3MeP][MeO)2PO2] ionic liquid required a long induction period, it did not form any tribolayer and no reduction of friction coefficient, yielding instead a high abrasion and adhesion mechanism. Thus, it can be concluded that bis(trifluoromethanesulfonyl)amide anion is more effective than dimethylphosphate in generating a surface protective film on the titanium surface under the selected test conditions and the testing methodology seems to be useful to understand the tribodesorption mechanism.The partners would like to acknowledge the financing to the Austrian Government financing of COMET K2 Excellence Centre of Tribology called X-Tribology to carry out this research collaborative activity. The authors also would like to acknowledge the financing of the EMAITEK Programme by the Basque Country